Oral abstracts 7: Molecular mechanisms of disease—osteoarthritisS1. Identification of novel osteoarthritis genes using zebrafishS2. Isn adrenomedullin a potential therapeutic for osteoarthritis, while its truncated peptide 22-52 acts as a pro-dege

摘要

Background: Osteoarthritis (OA) affects tens of millions of people worldwide. Twin studies and human GWAS have shown that there is a strong genetic component to the disease, however, to date relatively few genes have been linked to OA onset and progression. Using zebrafish, a genetically tractable organism, we aim to identify novel genes relevant to OA.