Development and Validation of Gas Chromatography/Mass Spectrometry Method for the Simultaneous Determination of Some Preservatives in Personal Care, Cosmetics and Pharmaceutical Formulations

摘要

The present work describes a method for simultaneous determination of four p-hydroxy benzoates (parabens) preservatives in cosmetics, personal care and pharmaceuticals formulations. The method blends liquid-liquid extraction and gas chromatography mass spectrometry in electron impact ionization positive mode. The various influencing parameters were optimized and validated. Chromatographic separation was achieved on BP-5 capillary column with short run time of 8.13 minutes. Linearity of the method was excellent for all analytes with regression coefficient values (R-) > 0.993. The method was successfully applied to commercially available formulations. The developed method can be used in routine every day analysis by testing and quality control laboratories.