Comparison of Sm complexes with Sn compounds for syntheses of copolymers composed of lactide and ε-caprolactone and their biodegradabilities

摘要

The comparison of organolanthanide complexes, (C_5Me_5)_2SmMe(THF) (Sm1) and [(C_5Me_5)_2Sm]_2(PhC=C= C=CPh) (Sm2), with tin compounds, Bu_2Sn(OMe)_2 (Sn1) and Bu_2Sn(OCH_2CH_2CH_2O) (Sn2), in the preparation of random and diblock copolymers composed of L-lactide (L-LA) or D,L-LA and s-caprolactone (CL), and the preparation of triblock copolymers composed of L-LA/CL/L-LA was studied and the biodegradabilities of the resulting copolymers with proteinase K and a compost were examined. Poly(L-LA-ran-CL) shows much higher degradability than poly(L-LA) with proteinase K, and poly(L-LA), poly(L-LA-ran-CL) and poly(L-LA-b-CL) (b means block) prepared with Sml had better degradability than those synthesized with the Snl compound. The degradability of poly(L-LA-ran-CL) with proteinase K is higher than that of poly(L-LA-b-CL). Poly(LA-ran-CL) and poly(LA-b-CL) prepared with Sm1 revealed higher degradability than those obtained with Snl using a compost. Triblock copolymers, poly(L-LA-b-CL-b-L-LA), synthesized with Sm2 revealed nearly the same degradability with those obtained with Sn2 using a compost. Finally, biocompatibility was studied with macrophage activation assay using RAW 264.7, and metabolic viability assay using Cell Titer Aqueous non-radioactive Cell.