We describe five patients with glomerulonephritis (GN) associated with cerebrospinal fluid shunt insertion to relieve hydrocephalus. A ventriculo-atrial (V-A) shunt had been placed on average 12.5 years prior to the diagnosis of nephritis (range 0.5-21 years). Four patients developed membranoprolifera-tive glomerulonephritis (MPGN) with associated hypocomplementaemia. A single patient developed focal proliferative glomerulonephritis. Coagulase-negative staphylococci were cultured in four patients, either from blood or from the shunt. Four patients had their shunts removed, two of whom also received antibiotics. The other patient received antibiotics alone for infective endocarditis due to staphylococcal bacteraemia which originated in the shunt. All patients had substantial renal impairment at the time of diagnosis (GFR, glomerular filtration rate, 20-45 ml/min). There was significant improvement in renal function after appropriate treatment; four of the five patients doubled their GFRs and two patients regained normal function.
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机译：我们描述了5例伴有脑脊液分流术以减轻脑积水的肾小球肾炎（GN）患者。在诊断为肾炎之前平均12.5年进行心房分流（V-A）（范围0.5-21年）。四名患者发生了膜增生性肾小球肾炎（MPGN），伴有低补体血症。一名患者发展为局灶性增生性肾小球肾炎。用血液或分流在四名患者中培养凝固酶阴性葡萄球菌。移除了四名患者的分流器，其中两名还接受了抗生素治疗。另一名患者因分流产生的葡萄球菌菌血症仅接受了感染性心内膜炎的抗生素治疗。所有患者在诊断时均患有实质性肾脏损害（GFR，肾小球滤过率，20-45 ml / min）。适当治疗后肾功能明显改善； 5例患者中有4例的GFR增加了一倍，而2例患者恢复了正常功能。
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