Pregnancy and pregnancy outcome in hepatitis C type 1B

摘要

A large cohort of rhesus-negative women in Ireland were inadvertently infected with hepatitis C Virus following exposure to contaminated anti-D Immunoglobulin in 1977-8. This major iatrogenic Episode was discovered in 1994. We studied 36 Women who had been infected after their first Pregnancy, and compared them to an age-and Parity-matched control group of rhesus-positive Women. The presence of hepatitis C antibody was Confirmed in all 36 by enzyme-linked immuno- Sorbent assay and by recombinant immunoblot Assay, while 26 (72/100) of the cohort were HCV- RNA-positive (type 1b) on PCR testing.