The introduction of thin-surfacing over the last 25 years offered some initial short-term gains, particularly in noise reduction and installation advantages over traditional materials. The use of higher-performance cross-linked polymerized binders in these asphalts can now offer a long-term risk-reduction strategy offering extra confidence for prudent asset management. Longer-lasting binder technology offers asset managers increased confidence in achieving the required outcomes throughout a structure's design life. The use of superior technology does not come cheap, but premature failure is more expensive and politically unacceptable. As in so many areas of life, investing in the best technology available from the outset is often the key to successful procurement.
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机译:6.一种化合物,其包含具有根据20的EP-B1-2563920(SEQ ID NO:80)的具有由20个连接的核苷组成的核碱基序列的修饰的寡核苷酸,其中所述修饰的寡核苷酸包含:由十个连接的脱氧核苷组成的缺口片段;和由五个连接的核苷组成的5'翼区段; 3'翼段由五个连接的核苷组成;其中所述间隙片段位于5'侧翼片段和3'侧翼片段之间,其中每个侧翼片段的每个核苷包含2'-O-甲氧基乙基糖;其中修饰的寡核苷酸的每个胞嘧啶是5-甲基胞嘧啶,并且其中修饰的寡核苷酸的每个核苷间键是硫代磷酸酯键;特别是inotersen;及其衍生物,例如由EP-B1-2563920保护的其盐,包括钠盐。