The CRF1</sub> receptor antagonist antalarmin attenuates yohimbine-induced increases in operant alcohol self-administration and reinstatement of alcohol seeking in rats

Peter W. Marinelli; Douglas Funk; Walter Juzytsch; Stephen Harding; Kenner C. Rice; Yavin Shaham; A. D. Lê

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The CRF1 receptor antagonist antalarmin attenuates yohimbine-induced increases in operant alcohol self-administration and reinstatement of alcohol seeking in rats

机译：CRF1 受体拮抗剂antalarmin减弱育亨宾诱导的大鼠操作性酒精自我给药和寻求酒精的恢复的增加

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Yohimbine is an alpha-2 adrenoreceptor antagonist that provokes stress- and anxiety-like responses in both humans and laboratory animals. In rats, yohimbine increases operant alcohol self-administration and reinstates alcohol seeking. In this study, we assess whether these effects of yohimbine are attenuated by systemic injections of the corticotrotropin-releasing factor 1 (CRF1) receptor antagonist antalarmin.

机译：育亨宾是一种α-2肾上腺素受体拮抗剂，可在人类和实验动物中引起类似压力和焦虑的反应。在大鼠中，育亨宾增加了操作性酒精的自我管理并恢复了寻求酒精的能力。在这项研究中，我们评估了全身注射促肾上腺皮质激素释放因子1（CRF1 ）受体拮抗剂antalarmin是否会减弱育亨宾的这些作用。

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来源
《Psychopharmacology》 |2007年第3期|345-355|共11页
作者
Peter W. Marinelli; Douglas Funk; Walter Juzytsch; Stephen Harding; Kenner C. Rice; Yavin Shaham; A. D. Lê;
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作者单位

Department of Neuroscience Neurobiology of Alcohol Laboratory Centre for Addiction and Mental Health Toronto ON Canada;

Department of Neuroscience Neurobiology of Alcohol Laboratory Centre for Addiction and Mental Health Toronto ON Canada;

Department of Neuroscience Neurobiology of Alcohol Laboratory Centre for Addiction and Mental Health Toronto ON Canada;

Department of Neuroscience Neurobiology of Alcohol Laboratory Centre for Addiction and Mental Health Toronto ON Canada;

Department of Health and Human Services National Institutes of Health National Institute on Drug Abuse Intramural Research Program Baltimore MD USA;

Department of Health and Human Services National Institutes of Health National Institute on Drug Abuse Intramural Research Program Baltimore MD USA;

Department of Neuroscience Neurobiology of Alcohol Laboratory Centre for Addiction and Mental Health Toronto ON Canada;

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正文语种 eng
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关键词
Alcohol self-administration; Alpha-2 adrenoceptors; Corticosterone; CRF; CRF1 receptor; Relapse; Reinstatement; Stress; Noradrenaline;

机译：酒精自我给药;Alpha-2肾上腺素受体;皮质酮;CRF;CRF1受体;复发;恢复;压力;去甲肾上腺素;

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1. The CRF1 receptor antagonist antalarmin attenuates yohimbine-induced increases in operant alcohol self-administration and reinstatement of alcohol seeking in rats. [J] . Marinelli PW, Funk D, Juzytsch W, Psychopharmacology . 2007,第3期

机译：CRF1受体拮抗剂antalarmin减弱了育亨宾诱导的大鼠操作性酒精自我给药和酒精恢复的增加。
2. Dependence-induced increases in ethanol self-administration in mice are blocked by the CRF1 receptor antagonist antalarmin and by CRF1 receptor knockout. [J] . Chu K, Koob GF, Cole M, Pharmacology, Biochemistry and Behavior . 2007,第4期

机译：CRF1受体拮抗剂antalarmin和CRF1受体敲除可阻止依赖诱导的小鼠乙醇自我给药增加。
3. Enhanced AMPA receptor activity increases operant alcohol self-administration and cue-induced reinstatement [J] . CannadyR., FisherK.R., DurantB., Addiction biology . 2013,第1期

机译：增强的AMPA受体活性增加了酒精的自我管理和提示诱导的恢复
4. l-stepholidine, a naturally occurring dopamine D1 receptor agonist and D2 receptor antagonist, attenuates methamphetamine self-administration in rate [C] . Kai Yue, BaoMiao Ma, JunQiao Xing International Conference on Applied Sciences, Engineering and Technology . 2014

机译：L- StepHolidine，天然存在的多巴胺D1受体激动剂和D2受体拮抗剂，衰减甲基苯丙胺自我管理
5. Alterations in the seeking and self-administration of ethanol and anxiety-like behavior following exposure to yohimbine in rats selectively bred for high alcohol intake. [D] . Bertholomey, Megan Lee. 2011

机译：选择性摄入高酒精摄入的大鼠暴露于育亨宾后，对乙醇的寻求和自我管理的改变以及类似焦虑的行为。
6. Correction: Lesions of the Lateral Habenula Increase Voluntary Ethanol Consumption and Operant Self-Administration Block Yohimbine-Induced Reinstatement of Ethanol Seeking and Attenuate Ethanol-Induced Conditioned Taste Aversion [O] . -1

机译：矫正：外侧Ha管的病变增加了自愿乙醇的摄入和操作者的自我管理阻止育亨宾诱导的对乙醇的寻求恢复并减弱了乙醇诱导的条件化口味厌恶
7. Lesions of the lateral habenula increase voluntary ethanol consumption and operant self-administration, block yohimbine-induced reinstatement of ethanol seeking, and attenuate ethanol-induced conditioned taste aversion. [O] . Andrew K Haack, Chandni Sheth, Andrea L Schwager, 2014

机译：外侧缰核的病变增加了自愿乙醇消耗和操作性自我给药，阻断育亨宾诱导的乙醇寻求恢复，并减弱乙醇诱导的条件性味觉厌恶。

The CRF1 receptor antagonist antalarmin attenuates yohimbine-induced increases in operant alcohol self-administration and reinstatement of alcohol seeking in rats

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