Antipsychotic profile of rolipram: efficacy in rats and reduced sensitivity in mice deficient in the phosphodiesterase-4B (PDE4B) enzyme

Judith A. Siuciak; Douglas S. Chapin; Sheryl A. McCarthy; Ashley N. Martin

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Antipsychotic profile of rolipram: efficacy in rats and reduced sensitivity in mice deficient in the phosphodiesterase-4B (PDE4B) enzyme

机译：咯利普兰的抗精神病学特征：在大鼠中的功效和缺乏磷酸二酯酶-4B（PDE4B）酶的小鼠的敏感性降低

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摘要

Recent studies provide evidence for reduced phosphodiesterase-4B (PDE4B) as a genetic susceptibility factor as well as suggesting an association of several single nucleotide polymorphisms (SNPs) in PDE4B that are associated with an increased incidence of schizophrenia.

机译：最近的研究提供了降低的磷酸二酯酶-4B（PDE4B）作为遗传易感性的证据，并暗示了PDE4B中的几个单核苷酸多态性（SNP）与精神分裂症的发病率增加相关。

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来源
《Psychopharmacology》 |2007年第3期|415-424|共10页
作者
Judith A. Siuciak; Douglas S. Chapin; Sheryl A. McCarthy; Ashley N. Martin;
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作者单位

CNS Discovery Pfizer Global Research and Development Eastern Point Road Groton CT 06340 USA;

CNS Discovery Pfizer Global Research and Development Eastern Point Road Groton CT 06340 USA;

CNS Discovery Pfizer Global Research and Development Eastern Point Road Groton CT 06340 USA;

CNS Discovery Pfizer Global Research and Development Eastern Point Road Groton CT 06340 USA;

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正文语种 eng
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关键词
Phosphodiesterase; Knockout; Mouse; Schizophrenia; Psychosis; Conditioned avoidance; PCP; Amphetamine; Brain;

机译：磷酸二酯酶;敲除;小鼠;精神分裂症;精神病;有条件回避;五氯苯酚;苯丙胺;脑;

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1. Antipsychotic profile of rolipram: efficacy in rats and reduced sensitivity in mice deficient in the phosphodiesterase-4B (PDE4B) enzyme. [J] . Siuciak JA, Chapin DS, McCarthy SA, Psychopharmacology . 2007,第3期

机译：咯利普兰的抗精神病学特征：在大鼠中的功效和在缺乏磷酸二酯酶4B（PDE4B）酶的小鼠中的敏感性降低。
2. Behavioral and neurochemical characterization of mice deficient in the phosphodiesterase-4B (PDE4B) enzyme. [J] . Siuciak JA, McCarthy SA, Chapin DS, Psychopharmacology . 2008,第1期

机译：缺乏磷酸二酯酶4B（PDE4B）酶的小鼠的行为和神经化学特征。
3. Behavioral and neurochemical characterization of mice deficient in the phosphodiesterase-4B (PDE4B) enzyme [J] . Judith A. Siuciak, Sheryl A. McCarthy, Douglas S. Chapin, Psychopharmacology . 2008,第1期

机译：缺乏磷酸二酯酶4B（PDE4B）酶的小鼠的行为和神经化学特征
4. Rolipram-loaded polymeric micelle reduces inflammatory response and apoptosis in Rat Spinal Cord [C] . Christian Macks, So June Gwak, Michael Lynn, Society for Biomaterials annual meeting and exposition . 2017

机译：咯利普兰负载的聚合物胶束可减轻大鼠脊髓的炎症反应和细胞凋亡
5. Sensitivity to carcinogenesis is increased and chemopreventive efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice. [D] . Ramos-Gomez, Minerva. 2003

机译：在nrf2转录因子缺陷型小鼠中，对癌发生的敏感性增加，并且酶诱导剂的化学预防效力丧失。
6. Rolipram Prevents the Formation of Abdominal Aortic Aneurysm (AAA) in Mice: PDE4B as a Target in AAA [O] . Saray Varona, Lídia Puertas, María Galán, 2021

机译：Rolipram阻止在小鼠中形成腹主动脉瘤（AAA）：PDE4B作为AAA中的靶标
7. Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice [O] . Ramos-Gomez, Minerva, Kwak, Mi-Kyoung, Dolan, Patrick M., 2001

机译：对致癌作用的敏感性增加，酶诱导剂的化学保护功效在 nrf2转录因子缺陷小鼠
8. Efficacy and Comparative Effectiveness of Off-Label Use of Atypical Antipsychotics. Comparative Effectiveness Review Number 6 [R] . 2007

机译：非典型抗精神病药的非标签使用的功效和比较效果。比较效力评论第6号

Antipsychotic profile of rolipram: efficacy in rats and reduced sensitivity in mice deficient in the phosphodiesterase-4B (PDE4B) enzyme

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