An 11-Year-Old Boy with Ongoing Psychotic Symptoms

摘要

To summarize, early-onset schizophrenia, of which childhood-onset schizophrenia is a subtype, appears to be a severe variant of adult-onset schizophrenia with some striking differences in terms of: 1) insidious onset of symptoms, predominance of bizarre symptoms and negative features of psychosis; 2) more premorbid neurodevelopmental anomalies, including a history of obstetric complications, presence of neurological soft signs and worse cognitive functioning; 3) marked gray matter loss in characteristic back-to-front parieto-frontal-temporal pattern; and 4) a higher rate of cytogenetic abnormalities.