A 55-Year-Old Female with Schizophrenia, Weight Gain

摘要

A recent review of eight double blind, placebo-controlled trials concluded that metformin may attenuate weight gain in patients taking second-generation antipsychotics.6 Most of these trials, however, were short (12 to 16 weeks) and the dosage of metformin may not have been maximally titrated. [...] larger, better designed trials are needed to clarify the optimal use of metformin in this population.