Effect of Phospholipid Membrane on Conformation of Retro-Sequence Amyloid- beeta-Peptide 35-25 and Normal Amyloid-beeta-Peptide 25-35

摘要

Negatively-charged phospholipid membrane does not affect the random coil conformation of a non-neurotoxic amyloid-beeta-peptide having a retro-sequence 35-25 (Abeta 35-25), whereas it changes the conformation of a neurotoxic normal-sequence peptide A beeta 25-35 from a random coil to a beeta-sheet-like structure under the same condition. The formation of the ordered structure seems to be closely related to the expression of neurotoxicity.