The conserved Wobble uridine tRNA thiolase Ctu1-Ctu2 is required to maintain genome integrity

摘要

Modified nucleosides close to the anticodon are important for the proper decoding of mRNA by the ribosome. Particularly, the uridine at the first anticodon position (U34) of glutamate, lysine, and glu-tamine tRNAs is universally thiolated (S~2U34), which