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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Apolipoprotein A-I (apoA-I) and apoA-I mimetic peptides inhibit tumor development in a mouse model of ovarian cancer
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Apolipoprotein A-I (apoA-I) and apoA-I mimetic peptides inhibit tumor development in a mouse model of ovarian cancer

机译：载脂蛋白A-I（apoA-I）和apoA-I模拟肽抑制卵巢癌小鼠模型中的肿瘤发展

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摘要

We examined whether reduced levels of Apolipoprotein A-I (apoA-I) in ovarian cancer patients are causal in ovarian cancer in a mouse model. Mice expressing a human apoA-l transgene had (Ⅰ) increased survival (P < 0.0001) and (Ⅱ) decreased tumor development (P < 0.01), when compared with littermates, following injection of mouse ovarian epithelial papillary serous adenocarcinoma cells (ID-8 cells). ApoA-l mimetic peptides reduced viability and proliferation of ID8 cells and cis-platinum-resistant human ovarian cancer cells, arid decreased ID-8 cell-mediated tumor burden in C57BL/6J mice when administered subcutaneously or orally. Serum levels of lysophosphatidic acid, a well-characterized modulator of tumor cell proliferation, were significantly reduced (>50% compared with control mice, P < 0.05) in mice that received apoA-l mimetic peptides (administered either subcutaneously or orally), suggesting that binding and removal of lysophosphatidic acid is a potential mechanism for the inhibition of tumor development by apoA-l mimetic peptides, which may serve as a previously unexplored class of anticancer agents.
机译：我们在小鼠模型中检查了卵巢癌患者中载脂蛋白A-I（apoA-I）水平降低是否与卵巢癌有关。与同窝仔相比，在注射小鼠卵巢上皮乳头状浆液性腺癌细胞（ID-）后，表达人类apoA-1转基因的小鼠具有（Ⅰ）存活率提高（P <0.0001）和（Ⅱ）肿瘤发育降低（P <0.01）。 8个单元格）。当通过皮下或口服给药时，ApoA-1模拟肽降低ID8细胞和顺铂耐药性人卵巢癌细胞的活力和增殖，并减少ID-8细胞介导的C57BL / 6J小鼠的肿瘤负担。溶血磷脂酸（一种特征明确的肿瘤细胞增殖调节剂）的血清水平在接受apoA-1模拟肽（皮下或口服）的小鼠中显着降低（与对照小鼠相比，> 50％，P <0.05），表明溶血磷脂酸的结合和去除是通过载脂蛋白A-1模拟肽抑制肿瘤发展的潜在机制，其可作为先前未开发的一类抗癌剂。

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    Feng Su; Kathy R. Kozak; Satoshi lmaizumi; Feng Gao; Malaika W. Amneus; Victor Grijalva; Carey Ng; Alan Wagner; Greg Hough; Gina Farias-Eisner; G. M. Anantharamaiah; Brian J. Van Lenten; Mohamad Navab; Alan M. Fogelman; Srinivasa T. Reddy; Robin Farias-Eisner;

  • 作者单位

    Department of Obstetrics and Gynecology, University of California, Los Angeles, CA 90095-5347;

    Department of Obstetrics and Gynecology, University of California, Los Angeles, CA 90095-5347 ,Genentech Inc., San Francisco, CA 94080;

    Department of Medicine, and University of California, Los Angeles, CA 90095-5347;

    Department of Obstetrics and Gynecology, University of California, Los Angeles, CA 90095-5347;

    Department of Obstetrics and Gynecology, University of California, Los Angeles, CA 90095-5347;

    Department of Medicine, and University of California, Los Angeles, CA 90095-5347;

    Department of Obstetrics and Gynecology, University of California, Los Angeles, CA 90095-5347 ,Present address: Mesa Verde Venture Partners, San Diego, CA 92101;

    Department of Medicine, and University of California, Los Angeles, CA 90095-5347;

    Department of Medicine, and University of California, Los Angeles, CA 90095-5347;

    Department of Medicine, and University of California, Los Angeles, CA 90095-5347 ,Columbia University, New York, NY 10032;

    Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294;

    Department of Medicine, and University of California, Los Angeles, CA 90095-5347;

    Department of Medicine, and University of California, Los Angeles, CA 90095-5347;

    Department of Medicine, and University of California, Los Angeles, CA 90095-5347;

    Department of Obstetrics and Gynecology, University of California, Los Angeles, CA 90095-5347 ,Department of Medicine, and University of California, Los Angeles, CA 90095-5347 ,Department of Molecular and Medical Pharmacology, University of California, Los Angeles, CA 90095-5347;

    Department of Obstetrics and Gynecology, University of California, Los Angeles, CA 90095-5347;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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  • 入库时间 2022-08-18 00:41:30

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