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Long-term influence of normal variation in neonatal characteristics on human brain development

机译:新生儿特征正常变化对人脑发育的长期影响

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摘要

It is now recognized that a number of cognitive, behavioral, and mental health outcomes across the lifespan can be traced to fetal development. Although the direct mediation is unknown, the substantial variance in fetal growth, most commonly indexed by birth weight, may affect lifespan brain development. We investigated effects of normal variance in birth weight on MRI-derived measures of brain development in 628 healthy children, adolescents, and young adults in the large-scale multicenter Pediatric imaging, Neurocognition, and Genetics study. This heterogeneous sample was recruited through geographically dispersed sites in the United States. The influence of birth weight on cortical thickness, surface area, and striatal and total brain volumes was investigated, controlling for variance in age, sex, household income, and genetic ancestry factors. Birth weight was found to exert robust positive effects on regional cortical surface area in multiple regions as well as total brain and caudate volumes. These effects were continuous across birth weight ranges and ages and were not confined to subsets of the sample. The findings show that (I) aspects of later child and adolescent brain development are influenced at birth and (ii) relatively small differences in birth weight across groups and conditions typically compared in neuropsychiatric research (e.g.. Attention Deficit Hyperactivity Disorder, schizophrenia, and personality disorders) may influence group differences observed in brain parameters of interest at a later stage in life. These findings should serve to increase our attention to early influences.
机译:现在已经认识到,整个生命周期中的许多认知,行为和心理健康结果都可以追溯到胎儿发育。尽管直接调节尚不明确,但胎儿生长的显着差异(通常以出生体重来衡量)可能会影响大脑的寿命。在大规模的多中心儿科影像学,神经认知和遗传学研究中,我们调查了出生体重的正常变化对628名MRI健康儿童,青少年和年轻人的MRI得出的大脑发育的影响。此异质样本是通过美国地理位置分散的地点招募的。研究了出生体重对皮层厚度,表面积,纹状体和总脑容量的影响,控制了年龄,性别,家庭收入和遗传祖先因素的差异。研究发现出生体重对多个区域的区域皮质表面积以及大脑和尾状体的总体积具有强大的积极作用。这些影响在出生体重范围和年龄之间是连续的,并不局限于样本的子集。研究结果表明,(I)出生后儿童和青少年大脑发育的各个方面都会受到影响;(ii)在神经精神病学研究中通常比较的人群和状况之间的出生体重差异相对较小(例如,注意力缺陷多动障碍,精神分裂症和人格疾病)可能会影响到以后生活中在感兴趣的大脑参数中观察到的群体差异。这些发现应有助于提高我们对早期影响的关注。

著录项

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  • 作者单位

    Department of Psychology, University of Oslo, 0373 Oslo, Norway;

    Department of Psychology, University of Oslo, 0373 Oslo, Norway;

    Multimodal Imaging Laboratory, Departments of University of California at San Diego, La Jolla, CA 92037,NeurosciencesUniversity of California at San Diego, La Jolla, CA 92037;

    Multimodal Imaging Laboratory, Departments of University of California at San Diego, La Jolla, CA 92037,Radiology, University of California at San Diego, La Jolla, CA 92037;

    Multimodal Imaging Laboratory, Departments of University of California at San Diego, La Jolla, CA 92037,Center for Human Development, University of California at San Diego, La Jolla, CA 92037;

    Multimodal Imaging Laboratory, Departments of University of California at San Diego, La Jolla, CA 92037,Radiology, University of California at San Diego, La Jolla, CA 92037;

    Multimodal Imaging Laboratory, Departments of University of California at San Diego, La Jolla, CA 92037;

    Multimodal Imaging Laboratory, Departments of University of California at San Diego, La Jolla, CA 92037,Radiology, University of California at San Diego, La Jolla, CA 92037;

    Center for Human Development, University of California at San Diego, La Jolla, CA 92037;

    Center for Human Development, University of California at San Diego, La Jolla, CA 92037,Psychiatry,University of California at San Diego, La Jolla, CA 92037;

    Department of Psychiatry and Behavioral Sciences, University of California, Davis, CA 95817;

    Scripps Genomic Medicine, Scripps Translational Science Institute and Scripps Health, La Jolla,CA 92037;

    Scripps Genomic Medicine, Scripps Translational Science Institute and Scripps Health, La Jolla,CA 92037;

    Scripps Genomic Medicine, Scripps Translational Science Institute and Scripps Health, La Jolla,CA 92037;

    Scripps Genomic Medicine, Scripps Translational Science Institute and Scripps Health, La Jolla,CA 92037;

    Sackler Institute for Developmental Psychobiology, Weil Cornell Medical College, New York, NY 10065;

    Sackler Institute for Developmental Psychobiology, Weil Cornell Medical College, New York, NY 10065;

    Department of Medicine, University of Hawaii and Queen's Medical Center, Honolulu, HI 96813;

    Department of Psychiatry, University of Massachusetts Medical School, Boston, MA 01655;

    Sackler Institute for Developmental Psychobiology, Weil Cornell Medical College, New York, NY 10065;

    Kennedy Krieger Institute Kennedy Krieger Institute and Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205,Children's Hospital Boston, Harvard Medical School, Boston, MA 02115;

    Scripps Genomic Medicine, Scripps Translational Science Institute and Scripps Health, La Jolla,CA 92037;

    F. M. Kirby Research Center, Kennedy Krieger Institute and Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205;

    Kennedy Krieger Institute Kennedy Krieger Institute and Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205;

    Multimodal Imaging Laboratory, Departments of University of California at San Diego, La Jolla, CA 92037,NeurosciencesUniversity of California at San Diego, La Jolla, CA 92037,Radiology, University of California at San Diego, La Jolla, CA 92037,Psychiatry,University of California at San Diego, La Jolla, CA 92037,Cognitive Science, University of California at San Diego, La Jolla, CA 92037;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    neurodevelopmental; anterior cingulate; cortical area; magnetic resonance imaging;

    机译:神经发育前扣带皮质区域磁共振成像;
  • 入库时间 2022-08-18 00:40:33

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