Researchers have long suspected that the unchecked growth of cancer cells in solid tumors leads to the accumulation of solid stress, which reduces blood flow by collapsing in-tra-tumoral blood vessels. The resulting hypoxia, it is believed, promotes tumor progression via immunosup-pression, inflammation, invasion, and metastasis, and impedes the efficacy of chemo-, radio- and immunothera-pies. In Rakesh Jain's Inaugural Article, Triantafyllos Stylianopoulos et al. (pp. 15101-15108), present a simple technique to estimate the accumulated growth-induced stresses within animal and human tumors. According to the authors, freshly excised tumors can be cut in a specific way that relaxes growth-induced stresses and causes the tissues to deform in a measurable way.
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