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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Lipid-derived nanoparticles for immunostimulatory RNA adjuvant delivery
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Lipid-derived nanoparticles for immunostimulatory RNA adjuvant delivery

机译：脂质衍生的纳米颗粒用于免疫刺激性RNA佐剂的递送

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摘要

Activation of the innate immune system, which provides a nonspecific firstline defense against microbial invasion, is a crucial step in subsequently activating the more specificadaptive responses that can clear infections or cancersand provide long-term protection against reinfection. Without the need for previous exposure to a given pathogen, the innate immune system may naturally mount a rapid response to new infections (1).
机译：先天免疫系统的激活提供了针对微生物入侵的非特异性一线防御，是随后激活更特异性的适应性反应（可以清除感染或癌症并提供长期保护以防止再次感染）的关键步骤。无需事先暴露于给定的病原体，先天免疫系统自然可以对新感染做出快速反应（1）。

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    David N. Nguyen; Kerry P. Mahon; Ghania Chikh; Phillip Kim; Hattie Chung; Alain P. Vicari; Kevin T. Love; Michael Goldberg; Steve Chen; Arthur M. Krieg; Jianzhu Chen; Robert Langer; Daniel G. Anderson;

  • 作者单位

    Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02142,Present address: Stanford University School of Medicine, Stanford, CA, 94305;

    David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02142;

    Pfizer Vaccines Research Ottawa, Pfizer Canada Inc., Ottawa, ON, Canada;

    Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02142;

    David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02142;

    Pfizer Vaccines Research Ottawa, Pfizer Canada Inc., Ottawa, ON, Canada;

    David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02142;

    Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02142;

    David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02142;

    Pfizer Vaccines Research Ottawa, Pfizer Canada Inc., Ottawa, ON, Canada;

    David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02142;

    Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02142,David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02142,Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02142;

    Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02142,David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02142,Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02142,Massachusetts Institute of Technology, Building 76, Room 653, 500 Main Street, Cambridge, Massachusetts 02142;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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  • 正文语种 eng
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  • 入库时间 2022-08-18 00:40:21

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