Promotion of sleep mediated by the A_2a-adenosine receptor and possible involvement of this receptor in the sleep induced by prostaglandin D_2 in rats

摘要

A 6-hr continuous infusion of 2-[p-(2- carboxyethyl)phenylethylamino]-5'-N-ethylcarboxamidoad- enosine (CGS21680), a selective A_2a-adenosine agonist, into the subarachnoid space underlying the ventral surface region of the rostral basal forebrain, which has been defined as the prostaglandin (PG) D_2-sensitive sleep-promoting zone, at rates of 0.02, 0.2, 2.0, and 12 pmol/min increased slow-wave sleep (SWS) and paradoxical sleep (PS) in a dose-dependent manner up to 183/100 and 202/100 of their respective baseline levels.