In vivo activity-dependent plasticity at cortico-striatal connections: Evidence for physiological long-term potentiation

摘要

The purpose of the present study was to investigate in vivo the activity-dependent plasticity of gluta- matergic cortico-striatal synapses. Electrical stimuli were applied in the facial motor cortex and intracellular recordings were performed in the ipsilateral striatal projection field of this cortical area. Recorded cells exhibited the typical intrin- sic membrane properties of striatal output neurons and were identified morphologically as medium spiny type I neurons. Subthreshold cortical tetanization produced either short- term posttetanic potentiation or short-term depression of cortically-evoked excitatory postsynaptic potentials.