New Safe Method for Preparation of Sarin-Exposed Human Erythrocytes Acetylcholinesterase Using Non-Toxic and Stable Sarin Analogue Isopropyl p-Nitrophenyl Methylphosphonate and its Application to Evaluation of Nerve Agent Antidotes

Hikoto Ohta; Takeshi Ohmori; Shinichi Suzuki; Hiroshi Ikegaya; Koichi Sakurada; Takehiko Takatori

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New Safe Method for Preparation of Sarin-Exposed Human Erythrocytes Acetylcholinesterase Using Non-Toxic and Stable Sarin Analogue Isopropyl p-Nitrophenyl Methylphosphonate and its Application to Evaluation of Nerve Agent Antidotes

机译：使用非毒性和稳定的沙林类似物对硝基苯基甲基膦酸异丙酯制备沙辛暴露的人类红细胞乙酰胆碱酯酶的新安全方法及其在评估神经解毒剂中的应用

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摘要

A non-toxic and stable sarin analogue, isopropyl p-nitrophenyl methylphosphonate (INMP), was synthesized for safe preparation of sarin-exposed acetylcholinesterase (AChE).

机译：合成了无毒且稳定的沙林类似物对硝基苯基甲基膦酸异丙酯（INMP），用于安全制备沙林暴露的乙酰胆碱酯酶（AChE）。

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来源
《Pharmaceutical Research》 |2006年第12期|2827-2833|共7页
作者
Hikoto Ohta; Takeshi Ohmori; Shinichi Suzuki; Hiroshi Ikegaya; Koichi Sakurada; Takehiko Takatori;
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作者单位

Toxicology Section Department of Forensic Chemistry National Research Institute of Police Science 6-3-1 Kashiwa-no-ha Kashiwa Chiba 277-0882 Japan;

Chemical Warfare Section Department of Forensic Chemistry National Research Institute of Police Science 6-3-1 Kashiwa-no-ha Kashiwa Chiba 277-0882 Japan;

Physical Evidence Section Department of Forensic Chemistry National Research Institute of Police Science 6-3-1 Kashiwa-no-ha Kashiwa Chiba 277-0882 Japan;

Department of Forensic Biology National Research Institute of Police Science 6-3-1 Kashiwa-no-ha Kashiwa Chiba 277-0882 Japan;

Department of Forensic Biology National Research Institute of Police Science 6-3-1 Kashiwa-no-ha Kashiwa Chiba 277-0882 Japan;

National Research Institute of Police Science 6-3-1 Kashiwa-no-ha Kashiwa Chiba 277-0882 Japan;

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原文格式 PDF
正文语种 eng
中图分类
关键词
acetylcholinesterase; antidote; isopropyl p-nitrophenyl methylphosphonate (INMP); PAM; sarin;

机译：乙酰胆碱酯酶;解毒剂;对硝基苯基甲基膦酸异丙酯（INMP）;PAM;沙林;
入库时间 2022-08-18 02:26:33

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专利

1. New safe method for preparation of sarin-exposed human erythrocytes acetylcholinesterase using non-toxic and stable sarin analogue isopropyl p-nitrophenyl methylphosphonate and its application to evaluation of nerve agent antidotes. [J] . Ohta H, Ohmori T, Suzuki S, Pharmaceutical research . 2006,第12期

机译：使用无毒且稳定的沙林类似物对硝基苯基甲基膦酸异丙酯制备沙林暴露的人红细胞乙酰胆碱酯酶的新安全方法及其在评估神经毒剂解毒剂中的应用。
2. Nerve agent analogues that produce authentic soman, sarin, tabun, and cyclohexyl methylphosphonate-modified human butyrylcholinesterase. [J] . Gilley C, MacDonald M, Nachon F Chemical research in toxicology . 2009,第10期

机译：产生真正梭曼，沙林，塔宾和环己基甲基膦酸酯修饰的人丁酰胆碱酯酶的神经药类似物。
3. A new methodology for estimating nerve agent (Sarin (GB)/VX) casualties as a function of time: Implementing the human response injury profile nerve agent methodology [J] . Deena S. Disraelly, Terri J. Walsh, Robert A. Zirkle, Journal of Chemical Health and Safety . 2011,第5期

机译：一种估算随时间变化的神经毒剂（Sarin（GB）/ VX）伤亡人数的新方法：实现人的反应性损伤概况神经毒剂
4. Superquadric obstacle modeling and a danger evaluation method with applications in safe planning for human-safe industrial robots [C] . Najmaei Nima, Kermani Mehrdad R. Technologies for Practical Robot Applications, 2009. TePRA 2009 . 2009

机译：超二次障碍物建模及危险性评估方法在人机安全工业机器人安全规划中的应用
5. Structure of a prereaction complex between the nerve agent sarin its biological target acetylcholinesterase and the antidote HI-6 [O] . Anders Allgardsson, Lotta Berg, Christine Akfur, 2016

机译：神经物质沙林蛋白其生物学靶点乙酰胆碱酯酶和解毒剂HI-6之间的反应前复合物的结构
6. Comparison of inhibition kinetics of several organophosphates, including some nerve agent surrogates, using human erythrocyte and rat and mouse brain acetylcholinesterase [O] . Alper Coban, Russell L. Carr, Howard W. Chambers, 2016

机译：几种有机磷酸盐的抑制动力学的比较，包括一些神经剂替代物，使用人的红细胞和大鼠和小鼠脑胰岛乙酰胆碱酯酶
7. Structural Biology and Protein Engineering Approach to the Development of Antidotes Against the Inhibition of Human Acetylcholinesterase by OP-based Nerve Agents. [R] . Sussman, J. L., Tawfik, D. S. 2015

机译：结构生物学和蛋白质工程方法开发抗Op基神经毒剂抑制人乙酰胆碱酯酶的解毒剂。

New Safe Method for Preparation of Sarin-Exposed Human Erythrocytes Acetylcholinesterase Using Non-Toxic and Stable Sarin Analogue Isopropyl p-Nitrophenyl Methylphosphonate and its Application to Evaluation of Nerve Agent Antidotes

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