In Vitro Studies of Intestinal Permeability and Hepatic and Intestinal Metabolism of 8-Prenylnaringenin, a Potent Phytoestrogen from Hops (Humulus lupulus L.)

Dejan Nikolic; Yongmei Li; Lucas R. Chadwick; Richard B. van Breemen

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In Vitro Studies of Intestinal Permeability and Hepatic and Intestinal Metabolism of 8-Prenylnaringenin, a Potent Phytoestrogen from Hops (Humulus lupulus L.)

机译：体外研究渗透性啤酒花（Humulus lupulus L.）的有效植物雌激素8-戊基柚皮素的肠通透性以及肝和肠代谢。

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摘要

The absorption potential and metabolism of 8-prenylnaringenin (8-PN) from hops (Humulus lupulus L.) were investigated. 8-PN is a potent estrogen with the potential to be used for the relief of menopausal symptoms in women.

机译：研究了啤酒花（Humulus lupulus L.）对8-异戊烯基柚皮素（8-PN）的吸收潜力和代谢。 8-PN是一种有效的雌激素，具有缓解女性更年期症状的潜力。

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来源
《Pharmaceutical Research》 |2006年第5期|864-872|共9页
作者
Dejan Nikolic; Yongmei Li; Lucas R. Chadwick; Richard B. van Breemen;
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作者单位

Department of Medicinal Chemistry and Pharmacognosy UIC/NIH Center for Botanical Dietary Supplements Research College of Pharmacy University of Illinois at Chicago 833 S. Wood Street Chicago Illinois 60612-7231 USA;

Department of Medicinal Chemistry and Pharmacognosy UIC/NIH Center for Botanical Dietary Supplements Research College of Pharmacy University of Illinois at Chicago 833 S. Wood Street Chicago Illinois 60612-7231 USA;

Department of Medicinal Chemistry and Pharmacognosy UIC/NIH Center for Botanical Dietary Supplements Research College of Pharmacy University of Illinois at Chicago 833 S. Wood Street Chicago Illinois 60612-7231 USA;

Department of Medicinal Chemistry and Pharmacognosy UIC/NIH Center for Botanical Dietary Supplements Research College of Pharmacy University of Illinois at Chicago 833 S. Wood Street Chicago Illinois 60612-7231 USA;

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正文语种 eng
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关键词
Caco-2 cells; hops; liquid chromatography–mass spectrometry (LC–MS); metabolism; natural products; 8-prenylnaringenin;

机译：Caco-2细胞;啤酒花;液相色谱-质谱（LC-MS）;代谢;天然产物;8-异戊烯基柚皮素;

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1. In vitro studies of intestinal permeability and hepatic and intestinal metabolism of 8-prenylnaringenin, a potent phytoestrogen from hops (Humulus lupulus L.). [J] . Nikolic D, Li Y, Chadwick LR, Pharmaceutical research . 2006,第5期

机译：体外研究8-异戊烯基柚皮素的肠道通透性以及肝和肠的代谢，这是一种来自啤酒花的有效植物雌激素（Humulus lupulus L.）。
2. Eubacterium limosum Activates Isoxanthohumol from Hops (Humulus lupulus L.) into the Potent Phytoestrogen 8-Prenylnaringenin In Vitro and in Rat Intestine1–3, [J] . Sam Possemiers4 Sylvie Rabot5 Juan Carlos Espín6 Aurélia Bruneau5 Catherine Philippe5 Antonio González-Sarrías6 Arne Heyerick7 Francisco A. Tomás-Barberán6 Denis De Keukeleire7 and Willy Verstraete4* The Journal of Nutrition . 2008,第7期

机译：利莫平杆菌可将蛇麻草中的异黄腐酚激活到有效的植物雌激素8-苯丙氨酸柚皮苷中，并在大鼠肠道内1-3活化，
3. Metabolism of 8-prenylnaringenin, a potent phytoestrogen from hops (humulus lupulus), by human liver microsomes. [J] . Nikolic D, Li Y, Chadwick LR, Drug Metabolism and Disposition: The Biological Fate of Chemicals . 2004,第2期

机译：人肝微粒体代谢啤酒花（（）中的有效植物雌激素8-异戊烯基柚皮素。
4. Comparison of in vitro intestinal and hepatic metabolism of diltiazem by ultra-performance liquid chromatography accurate mass spectrometry [C] . Joanna E. Barbara, Faraz Kazmi, Mark Horrigan, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2010

机译：用超高效液相色谱精确质谱法对Diltiazem的体外肠和肝代谢的比较
5. Analytical and bioassay studies of North American hop (Humulus lupulus L.) varieties and hop products for the potent phytoestrogen 8-prenylnaringenin. [D] . Eri, Sanja. 2001

机译：北美蛇麻草（Humulus lupulus L.）品种和蛇麻草产品的有效植物雌激素8-异戊烯基柚皮素的分析和生物分析研究。
6. In vitro studies of intestinal permeability and hepatic and intestinal metabolism of 8-prenylnaringenin a potent phytoestrogen from hops (Humulus lupulus L.) [O] . Dejan Nikolic, Yongmei Li, Lucas R. Chadwick, -1

机译：啤酒花（Humulus lupulus L.）有效的植物雌激素8-异戊烯基柚皮素的肠通透性以及肝和肠代谢的体外研究
7. Eubacterium limosum activates isoxanthohumol from hops (Humulus lupulus L.) into the potent phytoestrogen 8-prenylnaringenin in vitro and in rat intestine [O] . Possemiers Sam, RABOT Sylvie, ESPIN Juan carlos, 2008

机译：Eubacterium limosum在体外和大鼠肠中激活啤酒花（Humulus lupulus L.）中的异黄腐酚成为有效的植物雌激素8-异戊烯基柚皮素

In Vitro Studies of Intestinal Permeability and Hepatic and Intestinal Metabolism of 8-Prenylnaringenin, a Potent Phytoestrogen from Hops (Humulus lupulus L.)

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