An In Silico Transwell Device for the Study of Drug Transport and Drug–Drug Interactions

Lana X. Garmire; David G. Garmire; C. Anthony Hunt

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An In Silico Transwell Device for the Study of Drug Transport and Drug–Drug Interactions

机译：用于药物运输和药物相互作用的In Silico Transwell装置

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摘要

Validate and exemplify a discrete, componentized, in silico, transwell device (ISTD) capable of mimicking the in vitro passive transport properties of compounds through cell monolayers. Verify its use for studying drug–drug interactions.

机译：验证并举例说明一种能够模拟化合物通过细胞单层的体外被动转运特性的离散的，组分化的，计算机化的穿孔装置（ISTD）。验证其在研究药物相互作用中的用途。

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来源
《Pharmaceutical Research》 |2007年第12期|2171-2186|共16页
作者
Lana X. Garmire; David G. Garmire; C. Anthony Hunt;
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作者单位

Graduate Group in Comparative Biochemistry University of California Berkeley California USA;

The Berkeley Sensor and Actuator Center UC Berkeley Berkeley California USA;

BioSystems Group and the UCSF/UCB Joint Graduate Group in Bioengineering Department of Biopharmaceutical Sciences University of California 513 Parnassus Ave. S-926 San Francisco California 94143-0446 USA;

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原文格式 PDF
正文语种 eng
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关键词
agent-based modeling; discrete event; drug transport; drug–drug interaction; emergent properties; simulation;

机译：基于主体的建模;离散事件;药物运输;药物与药物相互作用;新兴特性;模拟;

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专利

1. An in silico transwell device for the study of drug transport and drug-drug interactions. [J] . Garmire LX, Garmire DG, Hunt CA Pharmaceutical research . 2007,第12期

机译：一种用于药物运输和药物-药物相互作用研究的计算机模拟穿孔装置。
2. Transwell-grown HepG2 cell monolayers as in vitro permeability model to study drug-drug or drug-food interactions. [J] . Berginc K, Kristl A Journal of medicinal food . 2011,第1a2期

机译：Transwell生长的HepG2细胞单层作为体外渗透性模型，用于研究药物-药物或药物-食物的相互作用。
3. Adverse drug reactions caused by drug-drug interactions reported to Croatian Agency for Medicinal Products and Medical Devices: a retrospective observational study. [J] . Mirosevic Skvrce N, Macolic Sarinic V, Mucalo I, Croatian medical journal . 2011,第5期

机译：向克罗地亚药品和医疗器械局报告的由药物相互作用引起的药物不良反应：一项回顾性观察研究。
4. Neural System for in silico Drug-Drug Interaction Screening [C] . Polak, S., Brandys, . 2005

机译：用于计算机药物相互作用筛选的神经系统
5. Fexofenadine and organic anion transporting polypeptides (OATPs): Transport and drug-drug interactions. [D] . Flynn, Colleen Ann. 2011

机译：非索非那定和有机阴离子转运多肽（OATP）：转运和药物相互作用。
6. Adverse drug reactions caused by drug-drug interactions reported to Croatian Agency for Medicinal Products and Medical Devices: a retrospective observational study [O] . Nikica Mirošević Skvrce, Viola Macolić Šarinić, Iva Mucalo, 2011

机译：向克罗地亚药品和医疗器械局报告的由药物相互作用引起的药物不良反应：一项回顾性观察研究
7. Adverse drug reactions caused by drug-drug interactions reported to Croatian Agency for Medicinal Products and Medical Devices: a retrospective observational study [O] . Mirošević Skvrce, Nikica, Macolić Šarinić, Viola, Mucalo, Iva, 2011

机译：向克罗地亚药品和医疗器械局报告的由药物相互作用引起的药物不良反应：一项回顾性观察研究

An In Silico Transwell Device for the Study of Drug Transport and Drug–Drug Interactions

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