Stabilization of a Supersaturated Solution of Mefenamic Acid from a Solid Dispersion with EUDRAGIT® EPO

Taro Kojima; Kenjirou Higashi; Toyofumi Suzuki; Kazuo Tomono; Kunikazu Moribe; Keiji Yamamoto

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Stabilization of a Supersaturated Solution of Mefenamic Acid from a Solid Dispersion with EUDRAGIT® EPO

机译：使用EUDRAGIT® EPO稳定固体分散剂中的甲芬那酸过饱和溶液

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摘要

The stabilization mechanism of a supersaturated solution of mefenamic acid (MFA) from a solid dispersion with EUDRAGIT® EPO (EPO) was investigated.

机译：研究了EUDRAGIT®EPO（EPO）固相分散液中甲芬那酸（MFA）过饱和溶液的稳定机理。

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来源
《Pharmaceutical Research》 |2012年第10期|p.2777-2791|共15页
作者
Taro Kojima; Kenjirou Higashi; Toyofumi Suzuki; Kazuo Tomono; Kunikazu Moribe; Keiji Yamamoto;
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作者单位

Chiba University, Chiba, Japan;

Chiba University, Chiba, Japan;

Chiba University, Chiba, Japan;

Chiba University, Chiba, Japan;

Chiba University, Chiba, Japan;

Chiba University, Chiba, Japan;

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原文格式 PDF
正文语种 eng
中图分类
关键词
solid dispersion; supersaturation; NMR; oral bioavailability; EUDRAGIT® EPO;

机译：固体分散体;过饱和;NMR;口服生物利用度;EUDRAGIT®EPO;

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专利

1. Stabilization of a supersaturated solution of mefenamic acid from a solid dispersion with EUDRAGIT? EPO [J] . KojimaT., HigashiK., SuzukiT., Pharmaceutical research . 2012,第10期

机译：用EUDRAGIT稳定固体分散液中的甲芬那酸过饱和溶液？欧洲专利局
2. Insights into atomic-level interaction between mefenamic acid and Eudragit EPO in a supersaturated solution by high-resolution magic-angle spinning NMR spectroscopy [J] . HigashiK., YamamotoK., PandeyM.K., Molecular pharmaceutics . 2014,第1期

机译：高分辨率魔角旋转NMR光谱洞察过饱和溶液中甲芬那酸和Eudragit EPO之间的原子级相互作用
3. Insights into atomic-level interaction between mefenamic acid and Eudragit EPO in a supersaturated solution by high-resolution magic-angle spinning NMR spectroscopy [J] . HigashiK., YamamotoK., PandeyM.K., Molecular pharmaceutics . 2014,第1期

机译：高分辨率魔法旋转NMR光谱探讨梅多芬酸与eudragit ePO在超饱和溶液中的原子水平相互作用的见解
4. Manufacture of Ternary Solid Dispersions Composed of Nifedipine, Eudragit E and Adsorbent [C] . Pornsak Sriamornsak, Srisuda Kontong, Yotsanan Weerapol, International Conference on Advanced Design and Manufacturing Engineering . 2011

机译：由硝苯地平，Eudragit E和吸附剂组成的三元固体分散体的制造
5. Mefenamic acid – HPMC AS HG Amorphous Solid Dispersions: Dissolution Enhancement Using Hot Melt Extrusion Technology [D] . Shukla, Ashay 2019

机译：甲芬那酸– HPMC AS HG非晶态固体分散体：使用热熔挤出技术提高溶解度
6. Insights into Atomic-level Interaction between Mefenamic Acid and Eudragit® EPO in a Supersaturated Solution by High-Resolution Magic-Angle Spinning NMR Spectroscopy [O] . Kenjirou Higashi, Kazutoshi Yamamoto, Manoj Kumar Pandey, -1

机译：高分辨率魔角旋转NMR光谱深入研究过饱和溶液中甲芬那酸和Eudragit®EPO之间的原子级相互作用
7. Stabilization mechanism of nitrazepam supersaturated state in nitrazepam/Eudragit®EPO/saccharin solution revealed by NMR measurements [O] . Harunobu Kanaya, Keisuke Ueda, Kenjirou Higashi, 2016

机译：通过NmR测量揭示硝西泮/Eudragit®EpO/糖精溶液中硝西泮过饱和态的稳定机制

Stabilization of a Supersaturated Solution of Mefenamic Acid from a Solid Dispersion with EUDRAGIT® EPO

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