N-glycan PK Profiling Using a High Sensitivity nanoLCMS Work-Flow with Heavy Stable Isotope Labeled Internal Standard and Application to a Preclinical Study of an IgG1 Biopharmaceutical

Fabian Higel; Andreas Seidl; Uwe Demelbauer; Margot Viertlboeck-Schudy; Vera Koppenburg; Ulrich Kronthaler; Fritz Sörgel; Wolfgang Frieß

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N-glycan PK Profiling Using a High Sensitivity nanoLCMS Work-Flow with Heavy Stable Isotope Labeled Internal Standard and Application to a Preclinical Study of an IgG1 Biopharmaceutical

机译：使用高灵敏度nanoLCMS工作流和重度稳定同位素标记的内标物进行N-聚糖PK分析，并将其应用于IgG1生物制药的临床前研究

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《Pharmaceutical Research》 |2015年第11期|3649-3659|共11页
作者
Fabian Higel; Andreas Seidl; Uwe Demelbauer; Margot Viertlboeck-Schudy; Vera Koppenburg; Ulrich Kronthaler; Fritz Sörgel; Wolfgang Frieß;
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1. N-glycan PK Profiling Using a High Sensitivity nanoLCMS Work-Flow with Heavy Stable Isotope Labeled Internal Standard and Application to a Preclinical Study of an IgG1 Biopharmaceutical [J] . Higel Fabian, Seidl Andreas, Demelbauer Uwe, Pharmaceutical research . 2015,第11期

机译：N-Glycan PK分析使用高灵敏度纳米型工作流程，具有重稳定同位素标记的内标和应用于IgG1生物制药的临床前研究
2. Standard addition with internal standardisation as an alternative to using stable isotope labelled internal standards to correct for matrix effects-Comparison and validation using liquid chromatography- tandem mass spectrometric assay of vitamin D [J] . Hewavitharana Amitha K., Abu Kassim Nur Sofiah, Shaw Paul Nicholas Journal of chromatography, A: Including electrophoresis and other separation methods . 2018,第期

机译：具有内部标准化的标准添加作为使用稳定同位素标记的内标以校正矩阵效应的替代方案 - 使用液相色谱 - 串联质谱法测定维生素D的基质效应和验证
3. Multiple-Enzyme-Digestion Strategy Improves Accuracy and Sensitivity of Label- and Standard-Free Absolute Quantification to a Level That Is Achievable by Analysis with Stable Isotope-Labeled Standard Spiking [J] . Wisniewski Jacek R., Wegler Christine, Artursson Per Journal of proteome research . 2019,第1期

机译：多酶消化策略可提高标签和无标准的绝对定量的准确性和敏感性，以通过稳定同位素标记标准尖刺可实现的水平
4. Absolute quantification of targeted endogenous salivary peptides using heavy isotope-labeled internal standards and high resolution selected reaction monitoring mass spectrometry Title [C] . Reiko Kiyonami, Markus Hardt, Rosa Viner, ASMS Conference on Mass Spectrometry and Allied Topics . 2008

机译：使用重型同位素标记的内标和高分辨率选定反应监测质谱标题的绝对定量靶向内源性唾液肽的绝对定量
5. N-glycan PK Profiling Using a High Sensitivity nanoLCMS Work-Flow with Heavy Stable Isotope Labeled Internal Standard and Application to a Preclinical Study of an IgG1 Biopharmaceutical [O] . Fabian Higel, Andreas Seidl, Uwe Demelbauer, -1

机译：使用高灵敏度nanoLCMS工作流和重度稳定同位素标记的内标物进行N-聚糖PK分析并将其应用于IgG1生物制药的临床前研究
6. N-glycan PK Profiling Using a High Sensitivity nanoLCMS Work-Flow with Heavy Stable Isotope Labeled Internal Standard and Application to a Preclinical Study of an IgG1 Biopharmaceutical [O] . 2015

机译：使用高灵敏度nanoLCMS工作流和重度稳定同位素标记的内标物进行N-聚糖PK分析，并将其应用于IgG1生物制药的临床前研究

N-glycan PK Profiling Using a High Sensitivity nanoLCMS Work-Flow with Heavy Stable Isotope Labeled Internal Standard and Application to a Preclinical Study of an IgG1 Biopharmaceutical

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