Idiopathic hypereosinophilic syndrome (IHES) is a heterogeneous spectrum of disorders characterized by hypereosinophilia and the presence of dysfunction in various end organs without an identifiable underlying cause. Neurological manifestations, including peripheral neuropathy, encephalopathy and cerebral thromboembolic or hemorrhagic disorders, can exist with IHES. We present a unique case of a 14-year-old girl with IHES and encephalitis involving the right temporo-parieto-occipital cortex.
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