Application of a Domino Intramolecular Enyne Metathesis/Cross Metathesis Reaction to the Total Synthesis of (+)-8-epi-Xanthatin

摘要

The first total synthesis of the novel sesquiterpene lactone (+)-8-epAxanthatin (1) has been achieved starting from the commercially available ester 8.The synthesis features an asymmetric aldol reaction and palladium-catalyzed carbonylation/lactonization sequence leading to 4 and a domino ring-closing enyne metathesis/cross metathesis reaction to afford 1.