Efficient Synthesis of Trisimidazole and Glutaric Acid Bearing Porphyrins: Ligands for Active-Site Models of Bacterial Nitric Oxide Reductase

摘要

Ligands (1) for active-site models of bacterial nitric oxide reductase (NOR) have been efficiently synthesized.These compounds (1) feature three imidazolyl moieties and one carboxylic acid residue at the Fe_B site,which represent the closest available synthetic model ligands of NOR active center.The stereo conformations of these ligands are established on the basis of steric effects and ~1H NMR chemical shifts under the ring current effect of the porphyrin.