DBU-promoted ring-opening reactions of multi-substituted donor-acceptor cyclopropanes: access to functionalized chalcones with a quaternary carbon groupf

摘要

A convenient and straightforward strategy to synthesize Z-configuration chalcones with alkylcyanoacetate subunits via DBU-promoted ring-opening reactions of multi-substituted D-A cyclopropanes has been developed. This reaction did not require a transition metal catalyst and extra solvent, and haloalkanes acted as both an alkylation reagent and solvent.