First total synthesis of the 7-oxygenated carbazole alkaloids clauszoline-K,3-formyl-7-hydroxycarbazole,clausine M,clausine N and the anti-HIV active siamenol using a highly efficient palladium-catalyzed approach

摘要

Using a convergent palladium-catalyzed construction of the carbazole framework as the key step we have achieved a short synthesis of the 7-oxygenated carbazole alkaloids clauszoline-K,3-formyl-7-hydroxycarbazole,clausine C (clauszoline-L),clausine M,clausine N and the anti-HIV active siamenol.