Conformational and electronic effects on the regioselectivity of the glycosylation of different anomers of N-dimethylmaleoyl-protected glucosamine acceptors

摘要

The differential reactivities of O3 and O4 towards glycosyl donors for α- and β-anomers of 6-O-protected/N-dimethylmaleoyl (DMM)-substituted glucosamine derivatives can be explained using state-of-the-art molecular modeling of acceptor analogs. Whereas th