Organocatalytic tandem three-component reaction of aldehyde, alkyl vinylketone, and amide: one-pot syntheses of highly functional alkenesf

摘要

An EtPPh_2- or PPh_3-catalyzed tandem three-component reaction of aldehyde, alkyl vinyl ketone, and amide is developed. Its further application in one-pot syntheses of highly functional alkenes starting from aldehydes, alkyl vinyl ketones, and amides is realized. A wide variety of highly functional etones can be furnished in 68-99% yields with high stereoselectivity {E/Z up to 98:2) within overall 3-29.5 h.