A highly sensitive fluorescent probe based on simple pyrazoline for Zn~(2+) in living neuron cells

摘要

We develop a pyrazoline-based fluorescent sensor for biological Zn~(2+) detection. The sensor shows good binding selectivity for Zn~(2+) over competing metal with 40-fold fluorescence enhancement in response to Zn~(2+). The new probe is cell-permeable and can be used to detect intracellular zinc ions in living neuron cells.