Non-Hybridization Saturable Mechanisms Play a Role in the Uptake of 68Ga-Labeled LNA–DNA Mixmer Antisense Oligonucleotides in Rats

Gabor Lendvai; Azita Monazzam; Irina Velikyan; Barbro Eriksson; Raymond Josephsson; Bengt L?ngstr?m; Mats Bergstr?m; Sergio Estrada

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Non-Hybridization Saturable Mechanisms Play a Role in the Uptake of 68Ga-Labeled LNA–DNA Mixmer Antisense Oligonucleotides in Rats

机译：非杂交的饱和机制在大鼠中摄取68Ga标记的LNA–DNA混合反义寡核苷酸中发挥作用

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*These authors contributed equally to this work.

机译：* 这些作者同样为这项工作做出了贡献。

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《Oligonucleotides》 |2009年第3期|223-232|共10页
作者
Gabor Lendvai; Azita Monazzam; Irina Velikyan; Barbro Eriksson; Raymond Josephsson; Bengt L?ngstr?m; Mats Bergstr?m; Sergio Estrada;
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Uppsala Imanet, GEMS PET Systems, GE Healthcare, Uppsala, Sweden.|Department of Medical Sciences, Uppsala University Hospital, Uppsala, Sweden.;

Uppsala Imanet, GEMS PET Systems, GE Healthcare, Uppsala, Sweden.|Department of Oncology, Radiology, and Clinical Immunology, Uppsala University Hospital, Uppsala, Sweden.;

Uppsala Applied Science Lab, GEMS PET Systems, GE Healthcare, Uppsala, Sweden.;

Department of Endocrine Oncology, Uppsala University Hospital, Uppsala, Sweden.;

Novartis Pharma AG, Basel, Switzerland.;

Uppsala Imanet, GEMS PET Systems, GE Healthcare, Uppsala, Sweden.|Uppsala Applied Science Lab, GEMS PET Systems, GE Healthcare, Uppsala, Sweden.|Department of Biochemistry and Organic Chemistry, Uppsala University, Uppsala Biomedical Centre, Uppsala, Sweden.;

Department of Pharmaceutical Biosciences, Uppsala University, Uppsala Biomedical Centre, Uppsala, Sweden.;

Uppsala Imanet, GEMS PET Systems, GE Healthcare, Uppsala, Sweden.;

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1. Non-hybridization saturable mechanisms play a role in the uptake of (68)Ga-Labeled LNA-DNA mixmer antisense oligonucleotides in rats [J] . Lendvai G, Monazzam A, Velikyan I, Oligonucleotides . 2009,第3期

机译：非杂交的饱和机制在大鼠摄取（68）Ga-标签的LNA-DNA混合反义寡核苷酸中起作用
2. Biodistribution of 68Ga-Labeled LNA–DNA Mixmer Antisense Oligonucleotides for Rat Chromogranin-A [J] . Gabor Lendvai Irina Velikyan Sergio Estrada Barbro Eriksson Bengt Långström Mats Bergström Oligonucleotides . 2008,第1期

机译：68Ga标签的LNA–DNA混合反义寡核苷酸对大鼠嗜铬粒蛋白A的生物分布
3. Biodistribution of (68)Ga-Labeled LNA-DNA Mixmer Antisense Oligonucleotides for Rat Chromogranin-A. [J] . Lendvai G, Velikyan I, Estrada S, Oligonucleotides . 2008,第1期

机译：（68）Ga标签的LNA-DNA混合器反义寡核苷酸对大鼠嗜铬粒蛋白A的生物分布。
4. Local application of LNA-based antisense oligonucleotides in a strategy for spinal cord injury treatment [C] . Pedro Moreno, Rita Ferreira, Daniela Salvador, World biomaterials congress . 2016

机译：基于LNA的反义寡核苷酸在脊髓损伤治疗策略中的局部应用
5. Antisense oligonucleotides directed to the HIV-1 Rev Response Element: Effects of nucleotide modification on oligo binding affinity, nuclease stability, and cellular uptake. [D] . Prater, Chrissy E. 2006

机译：针对HIV-1 Rev反应元件的反义寡核苷酸：核苷酸修饰对寡核苷酸结合亲和力，核酸酶稳定性和细胞摄取的影响。
6. LNA/DNA mixmer-based antisense oligonucleotides correct alternative splicing of the SMN2 gene and restore SMN protein expression in type 1 SMA fibroblasts [O] . Aleksander Touznik, Rika Maruyama, Kana Hosoki, -1

机译：基于LNA / DNA混合器的反义寡核苷酸可纠正SMN2基因的可变剪接并恢复1型SMA成纤维细胞中SMN蛋白的表达
7. Specific RNP capture with antisense LNA /DNA mixmers [O] . Rogell, BM, Fischer, B, Rettel, M, 2017

机译：用反义LNA捕获特异性RNP / DNA混合器

Non-Hybridization Saturable Mechanisms Play a Role in the Uptake of 68Ga-Labeled LNA–DNA Mixmer Antisense Oligonucleotides in Rats

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