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首页> 外文期刊>Neurochemical Research >Na+, K+ ATPase Activity Is Reduced in Amygdala of Rats with Chronic Stress-Induced Anxiety-Like Behavior
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Na+, K+ ATPase Activity Is Reduced in Amygdala of Rats with Chronic Stress-Induced Anxiety-Like Behavior

机译:Na + ,K + ATP酶活性在慢性应激诱导的焦虑样行为大鼠的杏仁核中降低

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摘要

In this study, we examined the effects of two chronic stress regimens upon anxiety-like behavior, Na+, K+-ATPase activity and immunocontent, and oxidative stress parameters (antioxidant enzymes and reactive oxygen species production) in the amygdala. Male rats were subjected to chronic unpredictable and to chronic restraint stress for 40 days. Subsequently, anxiety-like behavior was examined. Both stressed groups presented increased anxiety-like behavior. Reduced amygdalal Na+, K+-ATPase activity in the synaptic plasma membranes was also observed, without alterations in the amygdala immunocontent. In addition, when analyzing oxidative stress parameters, only superoxide dismutase activity was decreased in the amygdala of animals subjected to unpredictable stress. We conclude that both models of chronic stress lead to anxiety-like behavior and decreased amygdalal Na+, K+-ATPase activity, which appears not to be related to oxidative imbalance. The relationship between this decreased activity and anxiety-like behavior remains to be studied.
机译:在这项研究中,我们研究了两种慢性应激方案对焦虑样行为的影响,Na + ,K + -ATPase活性和免疫含量以及氧化应激参数(抗氧化剂)酶和活性氧的产生)。雄性大鼠经受不可预测的慢性和慢性束缚压力40天。随后,检查了焦虑样行为。两个压力大的组都表现出增加的焦虑样行为。还观察到突触质膜中的杏仁核Na + ,K + -ATPase活性降低,而杏仁核的免疫含量没有改变。另外,当分析氧化应激参数时,仅在遭受不可预测的应激的动物的杏仁核中超氧化物歧化酶活性降低。我们得出的结论是,两种慢性应激模型均会导致焦虑样行为并降低杏仁核Na + ,K + -ATPase活性,这似乎与氧化失衡无关。活动减少与焦虑样行为之间的关系尚待研究。

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