Convection-enhanced delivery of a transforming growth factor-ss2 inhibitor trabedersen for recurrent high-grade gliomas: efficacy real or imagined?, in reference to Bogdahn et al. (Neuro-Oncology 2011;13:132-142)

Marc C Chamberlain

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Convection-enhanced delivery of a transforming growth factor-ss2 inhibitor trabedersen for recurrent high-grade gliomas: efficacy real or imagined?, in reference to Bogdahn et al. (Neuro-Oncology 2011;13:132-142)

机译：对流传输增强的转化生长因子-ss2抑制剂trabedersen用于复发性高级神经胶质瘤：疗效是真实的还是想象中的？，参考Bogdahn等。（神经肿瘤学2011; 13：132-142）

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Dr Bogdahn et al. reported on the convection-enhanced delivery (CED) of the transforming growth factor-(32 (TGF-p2) inhibitor trabedersen for recurrent high-grade glioma.1 The trial was designed as a randomized phase 2b study comparing two doses of trabedersen to chemotherapy, either temozolomide (TMZ) or procabazine-lomustine-vincristine (PCV). Several comments regarding the study I believe are warranted.

机译：Bogdahn博士等。报告了转化性生长因子-（32（TGF-p2）抑制剂trabedersen对复发性高级别胶质瘤的对流增强递送（CED）。1该试验被设计为随机2b期研究，比较了两种剂量的trabedersen与化学疗法，是替莫唑胺（TMZ）或普鲁巴嗪-洛莫司汀-长春新碱（PCV）。

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《Neuro-Oncology》 |2011年第5期|p.558-562|共5页
作者
Marc C Chamberlain;
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University of Washington Department of Neurology and Neurological Surgery Division of'Neuro-Oncology Fred Hutchinson Cancer Research Center Seattle Cancer Care Alliance;

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1. Response to MC Chamberlain: Convection-enhanced delivery of transforming growth factor-02 inhibitor trabedersen for recurrent high-grade gliomas: efficacy real or imagined?,in reference to W Wick and M Weller:Trabedersen to target transforming growth factor-p: when the journey is not the reward, in reference to Bogdahn et al.(Neuro-Oncology 2011 ;13:132 -142) [J] . Ulrich Bogdahn Neuro-Oncology . 2011,第5期

机译：对MC Chamberlain的反应：对流转移增强的转化生长因子02抑制剂trabedersen对复发性高级别神经胶质瘤的治疗：疗效是真实的还是可以想象的？，参考W Wick和M Weller：Trabedersen靶向转化生长因子-p：何时参考Bogdahn等人的观点，旅程不是奖励（Neuro-Oncology 2011; 13：132 -142）
2. Trabedersen to target transforming growth factor-p: when the journey is not the reward, in reference to Bogdahn et al. (Neuro-Oncology 2011 ;13:132-142) [J] . Wolfgang Wick, Michael Weller Neuro-Oncology . 2011,第5期

机译：Trabedersen的目标是转化生长因子-p：当旅程不是奖励时，请参考Bogdahn等人的文章。（神经肿瘤学2011; 13：132-142）
3. Response to MC Chamberlain: Convection-enhanced delivery of transforming growth factor-β2 inhibitor trabedersen for recurrent high-grade gliomas: efficacy real or imagined? in reference to W Wick and M Weller: Trabedersen to target transforming growth factor-β: when the journey is not the reward in reference to Bogdahn et al. (Neuro-Oncology 2011;13:132–142) [O] . Ulrich Bogdahn 2011

机译：对MC张伯伦的反应：对流转移增强的转化生长因子-β2抑制剂trabedersen对复发性高级别神经胶质瘤的治疗：疗效是真实的还是可以想象的？参考W Wick和M Weller：Trabedersen靶向转化生长因子-β：何时参考Bogdahn等人的观点旅程不是奖励。（神经肿瘤学2011； 13：132-142）
4. Response to MC Chamberlain: Convection-enhanced delivery of transforming growth factor-β2 inhibitor trabedersen for recurrent high-grade gliomas: efficacy real or imagined?, in reference to W Wick and M Weller: Trabedersen to target transforming growth factor-β: when the journey is not the reward, in reference to Bogdahn et al. (Neuro-Oncology 2011;13:132–142) [O] . Bogdahn, Ulrich 2011

机译：对MC张伯伦的反应：对流转移增强的转化生长因子-β2抑制剂trabedersen对复发性高级别神经胶质瘤的治疗：疗效是真实的还是可以想象的？，参考W Wick和M Weller：Trabedersen靶向转化生长因子-β：何时参考Bogdahn等人的观点，旅程不是奖励。（神经肿瘤学，2011； 13：132-142）

Convection-enhanced delivery of a transforming growth factor-ss2 inhibitor trabedersen for recurrent high-grade gliomas: efficacy real or imagined?, in reference to Bogdahn et al. (Neuro-Oncology 2011;13:132-142)

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