mTOR Complex 2-Regulated Aerobic Glycolysis in Glioblastoma

摘要

Like many other malignant tumors, glioblastoma (GBM) is characterized metabolically by aerobic glycolysis (the Warburg effect), by which the majority of nutrient glucose is converted to lactate. This allows not only energy production, but also a steady supply of carbon-containing precursors for macromolecular biosynthesis, facilitating cellular growth and proliferation. Identifying the precise mechanisms by which cancer cells mediate the Warburg effect could lead to significant therapeutic insights.