Defect in parathyroid-hormone-induced luminal calcium absorption in connecting tubules of Klotho mice

摘要

Background. Homozygous Klotho mutant mice (KL−/− mice) exhibit multiple phenotypes resembling human ageing. Increases in the ratio of urinary calcium to urinary creatinine (uCa/uCr) and in serum Ca concentration and decreases in urinary Cr excretion and serum parathyroid hormone (PTH) concentration were reported; however, precise information about renal Ca handling was not reported in these animals.