Haemodynamic and renal effects of endothelin receptor antagonism in patients with chronic kidney disease

Neeraj Dhaun; Charles J. Ferro; Anthony P. Davenport; William G. Haynes; Jane Goddard; and David J. Webb

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Haemodynamic and renal effects of endothelin receptor antagonism in patients with chronic kidney disease

机译：慢性肾病患者对内皮素受体拮抗作用的血流动力学和肾脏影响

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Background. Endothelin-1 (ET-1) has been implicated in the pathophysiology of chronic kidney disease (CKD) and ET receptor blockade has shown renoprotective effects in animals. We examined the haemodynamic and renal effects of an ET receptor antagonist, TAK-044, in patients with CKD.

机译：背景。内皮素-1（ET-1）与慢性肾脏病（CKD）的病理生理有关，并且ET受体阻滞已在动物中显示出肾脏保护作用。我们检查了ET受体拮抗剂TAK-044对CKD患者的血液动力学和肾脏作用。

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《Nephrology Dialysis Transplantation》 |2007年第11期|3228-3234|共7页
作者
Neeraj Dhaun; Charles J. Ferro; Anthony P. Davenport; William G. Haynes; Jane Goddard; and David J. Webb;
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Clinical Pharmacology Unit University of Edinburgh the Queen's Medical Research Institute 47 Little France Crescent Edinburgh. EH16 4TJ;

Clinical Pharmacology Unit Addenbrooke's Hospital University of Cambridge and;

Department of Renal Medicine Royal Infirmary of Edinburgh UK;

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1. Haemodynamic and renal effects of endothelin receptor antagonism in patients with chronic kidney disease. [J] . Dhaun N, Ferro CJ, Davenport AP, Nephrology, dialysis, transplantation: official publication of the European Dialysis and Transplant Association - European Renal Association . 2007,第11期

机译：慢性肾病患者对内皮素受体拮抗作用的血流动力学和肾脏影响。
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4. The Natural History of Chronic Kidney Disease Revisited-A 72-Month Mayo Health System Hypertension Clinic Practice-Based Research Network Prospective Report on End-Stage Renal Disease and Death Rates in 100 High-Risk Chronic Kidney Disease Patients: A Call for Circumspection [C] . Macaulay A.C. Onuigbo Conference on Peritoneal Dialysis . 2009

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5. Subtyping Chronic Kidney Disease Patients and Adiposity-Obesity Related Metabolomics Analyses: Findings from the Chronic Renal Insufficiency Cohort Study [D] . Zheng, Zihe. 2021

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机译：在慢性肾脏疾病和选择性内皮素A受体拮抗作用下血浆血浆内皮素-1肽浓度升高
7. Haemodynamic and renal effects of endothelin receptor antagonism in patients with chronic kidney disease [O] . N. Dhaun, C. J. Ferro, A. P. Davenport, 2007

机译：内皮素受体对慢性肾疾病患者内皮素受体拮抗作用的血液动力学和肾疗法

Haemodynamic and renal effects of endothelin receptor antagonism in patients with chronic kidney disease

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