Cohesin complexes have a central role in cell division, mediating the association between sister chromosomes. It now seems that cohesin binding is dynamic, adapting to changes in gene transcription. Dividing cells face the monumental task of providingeach progeny cell with a complete and accurate copy of the genome. During mitosis, the basic cell-division process, cells need to ensure that they send only one copy of every chromosome to each of the daughter cells. Cohesion between the two sister chromatids produced by chromosome duplication is essential to this process: following duplication, the sister chromatids are physically linked by an evolutionary conserved, ling-shaped protein complex known as cohesin.
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