A SYSTEMS APPROACH

摘要

Research associate Katie Hoadley works in a genetics wet lab, but she hasn't picked up a pipette for three years. On this particular morning, at the University of North Carolina at Chapel Hill, she scrolls through lines of computer code to identify patients who responded well to a breast-cancer treatment in a published clinical trial. Using algorithms based on gene-expression data from human breast-tumour cell lines, she is looking for molecular signatures that might help to predict which breast-cancer patients will be most amenable to the treatment.