VIP receptor link to schizophrenia

摘要

Based on genome-wide analysis of copy number variants in two large schizophrenia cohorts, Vacic et al. report a significant association between duplications within a region of chromosome 7 and schizophrenia. Using microduplication analysis, the region was narrowed down to 7q36.3, just upstream of a gene encoding vasoactive intestinal peptide receptor (VIPR2). Increased expression of VIPR2 in patients with schizophrenia implicates VIP signalling as a molecular mechanism underlying schizophrenia.