The director's cut

摘要

Many cellular responses to external stimuli are comparable to the integrated performances of musicians in an orchestra, as directed by the conductor. By elucidating cellular signalling pathways, scientists can identify the individual components underlying disease, and attempt pharmacological mitigation. These ambitious goals require groundbreaking approaches. One such tool is ribosome profiling - a global approach to assess active translation of cellular messenger RNA that provides an unprecedented picture of the regulation of protein synthesis.