Glycine receptor mechanism elucidated by electron cryo-microscopy

摘要

The strychnine-sensitive glycine receptor (GlyR) mediates inhibitory synaptic transmission in the spinal cord and brainstem and is linked to neurological disorders, including autism and hyperekplexia. Understanding of molecular mechanisms and pharmacology of glycine receptors has been hindered by a lack of high-resolution structures. Here we report electron cryo-microscopy structures of the zebrafish alpha 1 GlyR with strychnine, glycine, or glycine and ivermectin (glycine/ivermectin). Strychnin