In vivo and in simulated body fluid degradation behavior and biocompatibility evaluation of anodic oxidation-silane-chitosan-coated Mg-4.0Zn-0.8Sr alloy for bone application

摘要

With the development and progress of science and technology, magnesium and magnesium alloys have attracted more and more researchers' attention because of their excellent biocompatibility. However, rapid degradation rate of magnesium alloy in vivo seriously limits its application (Arthanari et al., n.d.; Cui et al., 2013 [1,2]). In order to solve this problem, the surface modification of Mg-4.0Zn-0.8Sr alloy was adopted in this paper. According to the requirements of orthopedic materials, anodizing coating (AO), silane coating (SA) and chitosan coating (CS) coating were prepared on its surface, and magnesium alloy was prepared into intramedullary nail, and the corrosion resistance and biocompatibility of the corresponding samples was evaluated. The experimental results show that the AO-SA-CS coating sample has higher corrosion resistance, in addition, it also shows good biocompatibility, such as lower hemolysis rate and normal platelet adhesion morphology. After implantation into the femur, the femur of rats recovered well and the kidney tissue was normal.