Fabrication of biocompatible antibacterial nanowafers based on HNT/PVA nanocomposites loaded with minocycline for burn wound dressing

摘要

Bacterial infections of burn wounds are a significant problem that usually slows or stops the process of burn wounds healing. The use of topical antibiotics based on a novel drug delivery system could overcome the limitations of burn wound healing. In this work, the development of new wound dressings based on nanocomposite film of polyvinyl alcohol (PVA) and halloysite nanotubes (HNT) for the delivery of minocycline was investigated. These elastomeric nanocomposites were prepared based on HNT surface modification by APTES and then PVA coating by LbL strategy. The resulting nanocomposites were characterized by FT-IR, XRD, zeta potential, Tg analysis, FESEM, and antibacterial studies. The biodegradability and water uptake of the film were evaluated, the results of which revealed the absorption of scarring and non-degradation of the nanocomposite during treatment. Because minocycline decomposes by light, increasing photostability was another goal that was achieved. The release profile of the drug from the nanocomposite was studied, and it was found to be consistent with the Korsmeyer-Peppas model. In-vitro studies showed the antibacterial effect of nanocomposite on exposure to Gram-positive and Gram-negative bacteria. Due to the properties of the resulting nanocomposite film, it can be considered as a promising candidate for wound healing. In-vivo studies, cell culture, neuroprotective and anti-inflammatory effects may be investigated to develop this wound dressing in the future.