The biomimetic design and 3D printing of customized mechanical properties porous Ti6A14V scaffold for load-bearing bone reconstruction

摘要

The Ti6Al4V alloy is one of themost commonly used in orthopedic surgery. Mechanical property of implant contributes important biological functions for load-bearing bone tissue reconstruction. There is a significant need for design and fabrication of porous scaffold with customized mechanical properties for bone tissue engineering. In this paper, bionic design and fabrication of porous implants were studied by using finite element analysis (FEA) and 3D printing techniques. Novel porous architectures were built up with diamond lattice pore structure arraying units. With finite element analysis, the structure weak points under pressure were simulated so that the mechanical properties of the implants were optimized. Porous implants with different porosities and mechanical propertieswere precisely fabricated by selected laser melting (SLM), one of powder bed fusion additive manufacturing techniques. The biocompatibility and repair effect were studied by in vivo experiments. Animal results indicated that the damaged load-bearing bones were well reconstructed. New generated bones embedded and fitted into the designed porous implants. The optimized design and precisely manufactured implants are conducive to bone tissue repair and reconstruction. (C) 2018 Elsevier Ltd. All rights reserved.