Localisation of a Tumor-associated Phenotype of Benz-aldehyde Dehydrogenase in Liver Carcinogenesis of Flounder by Quantitative Histochemistry

摘要

Aldehyde dehydrogenases (ALDHs) oxidize endogeneous reactive aldehydes including lipid peroxidation products (propionaldehyde, malondialdehyde) and are also inducible by xenobiotics like DDT and TCDD. ALDHs are found in injured livers and cancers of contaminant-exposed flounder (platichthys flesus L.) and showed identical characteristics as in hepatocellular carcinomas of rats By its cytosolic localization, the preferential oxidation of aromatic compounds (benzaldehyde), dependency on NADP as coenzyme and sensitivity to the spe- cific inhibitor disulfiram.