Expression of Branchial Flavin-Containing Monooxygenase is Directly Correlated with Salinity-Induced Aldicarb Toxicity in The Euryhaline Fish (Oryzias latipes)

摘要

Earlier studies in our laboratory have demonstrated a reduction of flavin-con- taining monooxygenase (FMO) activity when salt-water adapted euryhaline fish were transferred to water of less salinity. Since FMOs have been shown to be responsible for the bioactivation of the carbamate insecticide, aldicarb, to a more potent cholinesterase inhibitor, it would be predicted that euryhaline fish exposed to aldicarb at higher salinity should have greater levels of FMO and, hence, be more susceptible to aldicarb toxicity.