On the Design and Selection of Polychlorinated Biphenyls for Use in Biological Test Systems

摘要

The polychlorinated biphenyls (PCBs) consist of a large number of individual congeners with varying degree of chlorination and possible substitution patterns. No single congener can be used as a representative congener for the whole class of compounds.. multivariate chemical characterisation (principal component analysis) in combination with factorial design provide tools by which small sets of structurally representative congeners can be determined. These tools are sug- gested to be used in the design of biological experiments in order to introduce systematic structural variation in the congeners to be tested and to make it pos- sible to construct quantitative structure-activity relationships (OSARs).