Comparative analysis of sediment extracts from NOAA's bioeffects studies by the biomarker, P450 Reporter Gene System

摘要

Sediment samples collected from nine coastal and estuarine areas have been analyzed to determine response of a biomarker, P450 Reporter Gene System (RGS). This biomarker, using a transgenic cell line, detects the presence and potency of organic compounds that typically induce the CYP1A gene. Previous investigations have shown that sediments containing chemicals which produce a response of 60 or more μg/g of benzo[a]pyrene equivalents (B[a]PEq) also exhibited a degraded community structure. RGS data from all study areas combined (527 samples) show that the mean response is 22.7 μg/g B[a]PEq, and the mean upper 99/100 confidence interval is 32.