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首页> 外文期刊>Magnetic Resonance in Medicine >3D compressed sensing for highly accelerated hyperpolarized 13C MRSI with in vivo applications to transgenic mouse models of cancer
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3D compressed sensing for highly accelerated hyperpolarized 13C MRSI with in vivo applications to transgenic mouse models of cancer

机译:3D压缩感测用于高度加速的超极化13C MRSI,并在体内应用于癌症的转基因小鼠模型

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摘要

High polarization of nuclear spins in liquid state through hyperpolarized technology utilizing dynamic nuclear polarization has enabled the direct monitoring of 13C metabolites in vivo at a high signal-to-noise ratio. Acquisition time limitations due to T1 decay of the hyperpolarized signal require accelerated imaging methods, such as compressed sensing, for optimal speed and spatial coverage. In this paper, the design and testing of a new echo-planar 13C three-dimensional magnetic resonance spectroscopic imaging (MRSI) compressed sensing sequence is presented. The sequence provides up to a factor of 7.53 in acceleration with minimal reconstruction artifacts. The key to the design is employing x and y gradient blips during a fly-back readout to pseudorandomly undersample kf-kx-ky space. The design was validated in simulations and phantom experiments where the limits of undersampling and the effects of noise on the compressed sensing nonlinear reconstruction were tested. Finally, this new pulse sequence was applied in vivo in preclinical studies involving transgenic prostate cancer and transgenic liver cancer murine models to obtain much higher spatial and temporal resolution than possible with conventional echo-planar spectroscopic imaging methods. Magn Reson Med, 2010. © 2009 Wiley-Liss, Inc.
机译:通过利用动态核极化的超极化技术对液态核自旋进行高度极化,可以在体内以高信噪比直接监测 13 C代谢产物。由于超极化信号的T 1 衰减而导致的采集时间限制要求加速成像方法(例如压缩感测)以实现最佳速度和空间覆盖。本文提出了一种新型的回波平面 13 C三维磁共振波谱成像(MRSI)压缩感知序列的设计与测试。该序列提供了高达7.53的加速因子,并且重构伪影极少。设计的关键是在回读期间采用x和y梯度斑点来伪随机欠采样k f -k x -k y 空间。该设计在仿真和幻像实验中得到了验证,其中测试了欠采样的极限以及噪声对压缩感测非线性重建的影响。最后,这种新的脉冲序列在体内被用于涉及转基因前列腺癌和转基因肝癌鼠类模型的临床前研究中,从而获得比常规回波平面光谱成像方法更高的时空分辨率。 Magn Reson Med,2010年。©2009 Wiley-Liss,Inc.。

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  • 来源
    《Magnetic Resonance in Medicine 》 |2010年第2期| p.312-321| 共10页
  • 作者单位

    Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, California, USA|UCSF & UCB Joint Graduate Group in Bioengineering, University of California, San Francisco, San Francisco, California, USA;

    Department of Electrical Engineering, Stanford University, Stanford, California, USA;

    Department of Medicine, Division of Hematology/Oncology, University of California, San Francisco, San Francisco, California, USA;

    Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, California, USA;

    Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, California, USA;

    Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, California, USA|UCSF & UCB Joint Graduate Group in Bioengineering, University of California, San Francisco, San Francisco, California, USA;

    Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, California, USA|UCSF & UCB Joint Graduate Group in Bioengineering, University of California, San Francisco, San Francisco, California, USA;

    Department of Medicine, Division of Hematology/Oncology, University of California, San Francisco, San Francisco, California, USA;

    Department of Electrical Engineering, Stanford University, Stanford, California, USA;

    Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, California, USA|UCSF & UCB Joint Graduate Group in Bioengineering, University of California, San Francisco, San Francisco, California, USA;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    hyperpolarized 13C; dynamic nuclear polarization; compressed sensing; magnetic resonance spectroscopic imaging; cancer;

    机译:超极化 13 / sup C;动态核极化;压缩传感;磁共振波谱成像;癌症;

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